Zane, Isabelle

Isabelle Zane

PhD Student

Parts Group
Understanding human DNA function by engineering
Lehner Group
Programmable biology

Measuring the effect of mutations on transcription factors

I am a PhD student working on assays to measure the effect of mutations on transcription factors. My research involves deep mutational scanning to generate transcription factor mutants, and next generation sequencing to measure the effect of those mutants. I’m interested in how mutations affect the allostery and binding interfaces of transcription factors, and I am developing the assays to measure this.

My timeline

MSc. Bioinformatics at Imperial College London
BSc. Biochemistry at Imperial College London

Wellcome Sanger Institute

Programmes and Facilities

Programme

Generative and Synthetic Genomics

The Generative and Synthetic Genomics Programme combines large-scale data generation and artificial intelligence to lay the foundations for predictive and programmable ...