As a bioinformatician my role is to process and build pipelines for the large datasets we generate in exploring pre-cancer and ageing.
In our group we use ultra-deep sequencing, amongst other approaches, our team studies how oncogenic mutations alter the behaviour of stem cells during aging and the earliest stages of cancer development in the skin and oesophagus.
Mainly I focus on the processing, analysis interpreation and generating novel visualisations of NGS data. This data varies from regular DNA and RNAseq through to ATAC-seq, CRISPR and scRNA/perturbseq.
Throughout my career I have continually learned and developed novel approaches to analyse data from basic germline variant calling through to somatic allele-specific copy number and single cell analyses and making these pipelines repeatable using version control and containerisation.