Dr Connor Rogerson

Senior Staff Scientist

I am interested in transcription factors, how they work, and what happens when they stop working. Often diseases are associated with dysregulated transcription factors, therefore understanding how transcription factors work will also lead to insights into disease pathology. I am using single-cell technology at scale to profile the effect of transcription factors on gene expression. 

Transcription factors and their role in disease

Transcription factors are key molecules in orchestrating correct gene expression programmes at the correct time. How they operate and how they are regulated are therefore key to understanding their effect in health and disease. I use multi-omic approaches e.g. ATAC-seq and ChIP-seq to ascertain their genome-wide binding profiles. Currently I am using single-cell approaches at scale to profile the effects of transcription factors expression on gene expression. Here I am exploiting AI to uncover the transcription factor syntax that govern key gene expression programmes.

My timeline

• Senior Staff Scientist - Prof Jussi Taipale - Wellcome Sanger Institute 

• Senior Research Associate - Prof Jussi Taipale - University of Cambridge

• Research Associate - Prof Christian Frezza - University of Cambridge

• PhD Molecular Cancer Studies - University of Manchester

• BSc (Hons) Biochemistry - Newcastle University