Rebeca Olvera León

Research Assistant

I am interested in using CRISPR/Cas9-based gene editing to identify genetic changes that contribute to cancer development.

Saturation genome editing of RAD51C

I completed my master’s degree under the supervision of Dr. David Adams and Dr. Andrew Waters at the Wellcome Sanger Institute. My project investigated variants of uncertain significance (VUS) in RAD51C, a gene associated with breast and ovarian cancer predisposition. I used saturation genome editing (SGE) to systematically characterise all possible single-nucleotide variants in this gene. The findings of this study, now published in Cell, provide a valuable resource to aid in the clinical management of VUS and advance targeted therapies.

My timeline

• Research Assistant, Wellcome Sanger Institute

• MPhil in Biological Science, University of Cambridge 

• Bsc in Technology, National Autonomous University of Mexico

• Research student, International Laboratory for Human Genome Research, UNAM