Since 2018 I have been working within Mike Stratton’s research group as part of the Cancer Grand Challenges: Mutographs team, which aims to discover novel preventable causes of cancer by combining traditional cancer epidemiology with cancer genomics. Cancer epidemiology has been able to identify many risk factors for cancer, however, for some cancer types there remains substantial variation in cancer incidence rates that currently cannot be explained. Evidence of mutagenic exogenous exposures in human cancers can be detected via the distinct patterns of somatic mutations (mutational signatures) they produce. By comparing the mutational signature landscape of cancers from countries of varying incidence rate, it may be possible to identify previously unknown causes of cancer. My work focuses on performing mutational signature analysis in various cancer types using different methodologies, looking to further define the mutational signature landscape of a cancers as well as finding evidence of environmental exposures affecting cancer incidence rates.