Nithila Joseph

Postdoctoral Fellow

I use CRIPSR-Cas13d system to edit the transcriptome of cancer cells to understand oncopathology and identify drug targets.

Cas13d for effective transcriptome targeting

I am part of the OpenTargets project, Symphony, which aims to target the transcriptome of cancer cells using the CRISPR-Cas13d system. Cas13d offers several advantages, including reduced toxicity and knockdown rather than a knockout effect. By understanding how individual transcripts influence the progression of cancer, we hope to identify potential drug targets. Additionally, by targeting lncRNAs and isoform-switching events – both of which are relatively unexplored areas in cancer pathology – we aim to contribute to deeper understanding of cancer evolution.

My timeline

• Postdoctoral fellow, Wellcome Sanger Institute

• Postdoctoral fellow, Academia Sinica, Taiwan

• PhD (Biomedical Science), National Chung Hsing University, Taiwan

• BTech (Biotechnology), Tamil Nadu Agricultural University, India