International Cancer Genome Consortium for Medicine (ICGCmed) will link genomics to clinical information and health
The collaborative project will build upon the vast database of genomic discoveries of the ICGC, which, since its launch in 2007, has been mapping 25,000 different cancer genomes in 50 different tumour types and making this data freely available to qualified researchers around the world.
By linking the ICGC data with clinical information, ICGCmed aims to accelerate the movement of this information into the clinic to guide prevention, early detection, diagnosis and prognosis, and provide the information needed to match patients’ disease to the most effective combinations of therapy. ICGCmed research will apply to a broad spectrum of cancers, from early cancers through to metastases.
“ICGC was a major advance in cataloging a large number of gene alterations from different types of cancers. By collecting clinical information from large cohorts of patients that were classified as having the same types of cancer coupled with extensive genomic information, ICGCmed will allow us to determine genetic elements of the efficacy of treatment, and root out the causes of resistance to therapy. Ultimately, this will allow patients to receive the right treatment and for their treatment to be adapted effectively.”
Dr Fabien Calvo Chief Scientific Officer, Cancer Core Europe and the lead author of the ICGCmed white paper
“Collaboration between institutions across the world and open sharing of data with qualified researchers have been two pillars of ICGC’s success to date. I am proud to say that ICGCmed will continue the ICGC’s legacy, tapping into the ICGC’s vast catalogue of cancer data and applying it to the clinical setting where it can impact patients.”
Dr Tom Hudson President and Scientific Director of The Ontario Institute for Cancer Research and one of the founders of the ICGC
“Precision oncology has opened a new avenue for treating cancer patients based on DNA sequence data of the respective cancer genome. Alterations of the genomic information in tumour cells offer novel treatment options. However, in the day-to-day clinical situation, it would be highly beneficial to know which alterations have already been successfully attacked by which drug and in which tissue context. ICGCmed will align this information worldwide and thereby greatly contribute to a fast translation of genomic information into clinical treatment options.”
Dr Peter Lichter Head of the Division of Molecular Genetics at the German Cancer Research Center (DKFZ)
“During the past decade we have witnessed how the genomic information could shift the cancer treatment paradigm and improve the outcomes with changes of the natural history of many cancer types. Korean oncologic society is very excited to be joining ICGCmed. We are very proud to be part of ICGCmed, which will make an even greater impact on the clinical application of genomic information and bring precision oncology closer to the bedside to match the right patient with the right drug at the right time.”
Dr Keunchil Park Director of the Innovative Cancer Medicine Institute, Samsung Medical Center
“I look forward to the bold and ambitious aims of ICGCmed building on the achievements of ICGC and delivering knowledge over the next decade that will be ever more relevant to the clinical management and outlook of individual patients.”
Professor Sir Michael Stratton Director of the Wellcome Trust Sanger Institute and Chief Executive Officer of the Wellcome Genome Campus
“The Ontario government has been proud to support the ICGC in its goal to better understand the genetic origins of cancer. Our government recognizes the importance of supporting world-class studies and research talent at Ontario’s leading-edge institutions, and we are extremely excited about this next major step forward with the launch of ICGCmed and its potential impact on lives of Ontarians.”
Reza Moridi Ontario’s Minister of Research and Innovation
Researchers working with ICGCmed must also agree to share data while also protecting the privacy of study participants.
The original ICGC is slated for completion in 2018.
More information
For more information and updates about ICGCmed activities, please visit the website at: www.icgcmed.org
Selected websites
International Cancer Genome Consortium (ICGC)
The International Cancer Genome Consortium (ICGC) has been organized to launch and coordinate a large number of research projects that have the common aim of elucidating comprehensively the genomic changes present in many forms of cancers that contribute to the burden of disease in people throughout the world.
The primary goals of the ICGC are to generate comprehensive catalogues of genomic abnormalities (somatic mutations, abnormal expression of genes, epigenetic modifications) in tumors from 50 different cancer types and/or subtypes which are of clinical and societal importance across the globe and make the data available to the entire research community as rapidly as possible, and with minimal restrictions, to accelerate research into the causes and control of cancer. The ICGC facilitates communication among the members and provides a forum for coordination with the objective of maximizing efficiency among the scientists working to understand, treat, and prevent these diseases.
Ontario Institute for Cancer Research
German Cancer Research Center
The Wellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute is one of the world’s leading genome centers. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programs and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease.
