Anderson Group
Genomics of inflammation and immunity
The immune system must maintain a delicate balance; it should be sensitive enough to eliminate invading pathogens while being tolerant of the body’s own cells. Immune-mediated diseases can occur when the immune system gets this balance wrong and attacks cells and substances typically found in the body. These diseases are known to “run in families”, suggesting that inherited genetic risk factors play a role in susceptibility. The aim of our research is to improve our understanding of immune-mediated diseases by identifying and functionally characterising the specific regions of the genome that influence disease risk, progression and response to therapy. We undertake both computational and wet lab research in order to achieve these goals.
The Anderson Lab currently consists of 18 people from a diverse range of backgrounds, including genetics, mathematics, medicine, computer science, cell biology and immunology. To date, our research has focussed on the inflammatory bowel diseases (Crohn’s disease and ulcerative colitis), primary biliary cirrhosis and primary sclerosing cholangitis. Over 280 regions of the genome have been associated with at least one of these four diseases, and our group has played a key role in this success. We are currently undertaking whole-exome and whole-genome sequencing-based association studies across tens of thousands of IBD patients from the UKIBDGC and IBD BioResource to identify rare variants associated with IBD. We are collaborating closely with Mark Daly’s group at the Broad Institute, who are generating a similar dataset, to complete the genetic susceptibility map for IBD. By combining our genetics data with the rich phenotypic data that exists across the more than 30K UK IBD samples, including structured data ascertained from electronic health records, we are now identifying loci underpinning variation in disease course and drug response.
The majority of association signals identified via GWAS are driven by non-coding variants that influence disease risk by perturbing gene expression. However, our knowledge of the regulatory genome lags significantly behind that of the coding genome, making it difficult to know which genes are ultimately dysregulated to bring about disease. To tackle this problem for IBD, we are sequencing RNA ascertained from single-cells in the gut and blood from hundreds of IBD patients and controls. We are combining these data with DNA sequencing data to identify genetic variants that regulate gene expression in the many cell types within these disease-relevant tissues. We are working together with the pharmaceutical partners of Open Targets and Crohn’s Colitis Foundation to turn these data, and that from the rest of the research community, into candidate drug targets for IBD.
In our wet lab, we are currently undertaking genome-wide CRISPR screens using primary and iPSC-derived immune cells to identify the cellular mechanisms perturbed in IBD and better understand the biological basis of variation in drug response. We also undertake some functional follow-up work to understand the cellular mechanisms perturbed by variants identified in the studies outlined above.
We have a wide range of very exciting projects underway in our multidisciplinary team, and if you’d like to know more about these please visit www.andersonlab.info. We’re always on the lookout for motivated people to join the group, including those with personal fellowships who think a period of time working in the team will benefit their research. So, if you’re interested in our work, please send one of us an email and include your CV.
Core team
![Ben Bai Photo of Ben Bai](/userpics/200/bb9.jpg)
Ben Bai
PhD Student
![Carol Dunbar Photo of Carol Dunbar](/userpics/200/cd12.jpg)
Carol Dunbar
Personal Assistant to Head of Human Genetics and Senior Team Administrator
![Omar El Garwany Photo of Omar El Garwany](/userpics/200/oe2.jpg)
Omar El Garwany
PhD Student
![Dr Laura Fachal Photo of Dr Laura Fachal](/userpics/200/lf9.jpg)
Dr Laura Fachal
Senior Staff Scientist
![Dr Bradley Harris Photo of Dr Bradley Harris](/userpics/200/bh18.jpg)
Dr Bradley Harris
Postdoctoral Fellow
![May Hu Photo of May Hu](/userpics/200/xh2.jpg)
May Hu
Research Assistant
![Dr Monika Krzak Photo of Dr Monika Krzak](/userpics/placeholder.jpg)
Dr Monika Krzak
Postdoctoral Fellow
![Julie Matte Photo of Julie Matte](/userpics/200/jm52.jpg)
Julie Matte
PhD Student
![Sophie Miller Photo of Sophie Miller](/userpics/200/sl24.jpg)
Sophie Miller
Research Manager
![Mrs Laura Richardson Photo of Mrs Laura Richardson](/userpics/200/lh7.jpg)
Mrs Laura Richardson
Advanced Research Assistant
![Dr Michelle Strickland Photo of Dr Michelle Strickland](/userpics/200/ms64.jpg)
Dr Michelle Strickland
Senior Research Assistant
![Dr Michal Szpak Photo of Dr Michal Szpak](/userpics/200/ms30.jpg)
Dr Michal Szpak
Postdoctoral Fellow
![Maria Torra I Benach Photo of Maria Torra I Benach](/userpics/200/mt26.jpg)
Maria Torra I Benach
PhD Student
![Dr Yali Xue Photo of Dr Yali Xue](/userpics/200/ylx.jpg)
Dr Yali Xue
Senior Staff Scientist
Previous team members
![Tobi Alegbe Photo of Tobi Alegbe](/userpics/200/oa3.jpg)
Tobi Alegbe
PhD student
![Dr Elizabeth Goode Photo of Dr Elizabeth Goode](/userpics/200/eg13.jpg)
Dr Elizabeth Goode
Clinical PhD Student
![Dr Ewan Harrison Photo of Dr Ewan Harrison](/userpics/200/eh6.jpg)
Dr Ewan Harrison
Head of the Respiratory Virus and Microbiome Initiative (Group leader)
![Rachel Henry Photo of Rachel Henry](/userpics/200/rh25.jpg)
Rachel Henry
Team Administrator - Human Genetics
![Mr Sun-Gou Ji Photo of Mr Sun-Gou Ji](/userpics/200/sj4.jpg)
Mr Sun-Gou Ji
Research Associate
![Dr Carla Jones Photo of Dr Carla Jones](/userpics/200/cjb.jpg)
Dr Carla Jones
Senior Staff Scientist
![Paris Litterick Photo of Paris Litterick](/userpics/200/pl7.jpg)
Paris Litterick
Team Administrator
![Dr Loukas Moutsianas Photo of Dr Loukas Moutsianas](/userpics/200/lm12.jpg)
Dr Loukas Moutsianas
Postdoctoral Fellow
![Dr Velislava Petrova Photo of Dr Velislava Petrova](/userpics/200/vp5.jpg)
Dr Velislava Petrova
Postdoctoral Fellow
![Dan Rice Photo of Dan Rice](/userpics/200/dr9.jpg)
Dan Rice
Senior Software Developer
![Eva Serra Photo of Eva Serra](/userpics/200/egs.jpg)
Eva Serra
PhD Student
![Tejas Shah Photo of Tejas Shah](/userpics/200/ts8.jpg)
Tejas Shah
Senior Computer Biologist
![Dr Leland Taylor Photo of Dr Leland Taylor](/userpics/placeholder.jpg)
Dr Leland Taylor
Postdoctoral Fellow
![Dr Chris Tyler-Smith Photo of Dr Chris Tyler-Smith](/userpics/200/cts.jpg)
Dr Chris Tyler-Smith
Former Senior Group Leader
![Qian Zhang Photo of Qian Zhang](/userpics/200/qz2.jpg)
Qian Zhang
Postdoctoral Fellow
Associated research
Related groups
Programmes and Facilities
Partners
Our research is highly collaborative and we are fortunate to work with many great scientists and clinicians from all around the world.
External
UK Inflammatory Bowel Disease Genetics Consortium
The UKIBD Genetics Consortium (UKIBDGC) comprises clinicians and scientists from throughout the UK. The aim of the group is to identify and understand the regions of the genome that determine disease susceptibility, course and response to treatment.
External
The International IBD Genetics Consortium
The International IBD Genetics Consortium has brought together clinicians and scientists from around the world to put together a cohort of over 20,000 IBD patients and 40,000 controls. The UK IBD Genetics Consortium plays a central role in the IIBDGC.
External
UK-PBC
UK-PBC is a unique collaboration between patient groups, doctors, scientists and industry with a shared interest in increasing understanding about, and treatment for the autoimmune liver disease Primary Biliary Cirrhosis (PBC).
External
International PSC Study Group
The aim of the IPSCSG is to coordinate PSC research projects between leading acadmic institutions worldwide. Both basic and clinical research groups are represented, enabling translational research that would otherwise not be feasible.
External
Dr Tim Raine - Honorary Faculty
Dr Tim Raine is a practising clinician with an interest in inflammatory bowel diseases (IBD) and mucosal immunology. His research is focussed on understanding the regulation of the gastrointestinal immune system
External
Open Targets
Open Targets is an innovative, large-scale, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.
External
Crohn' Colitis Foundation
The Crohn's and Colitis Foundation is a volunteer-driven non-profit organization dedicated to finding cures for Crohn's disease and ulcerative colitis and improving the quality of life of children and adults affected by these digestive diseases.Carl is a member of the Foundation's Genetics Initiative, along with Ramnik Xavier (Broad Institute) and Thad Stappenbeck (Wash U), and they part-fund our single-cell gut eQTL work.