Flatworm Functional Genomics Initiative (FUGI)

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  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
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    Join our community of world class thinkers and professionals at the Sanger Institute located in Cambridge. Together we achieve life-changing science.
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    We are committed to training the next generation of pioneering genome scientists and clinicians. At the Wellome Sanger Institute we give PhD students and postdocs all the tools they need to succeed in the field of genomics research.
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  Our vision and mission is to deliver world-leading genomics research in collaboration with research partners across the globe. Discover how our funding gives our leadership the independence to conduct bold, ambitious science that pioneers new fields in health, disease and conservation.
  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
  - Our Vision
    By focusing on fundamental discovery research led by our faculty and employing our unique scale in cutting-edge data generation and analysis, we deliver discoveries not easily made elsewhere.
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    From providing fundamental resources for understanding biology to exploring cancer genomes and the effects of variation in human genomes, our work lays the foundations for personalised medicine. We also reveal the secrets of human development and how infectious diseases evolve and spread.
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  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
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  We play a pivotal role in helping to shape Government and International research policies. We also lead the way in developing guidance to support our scientists to carry out their research ethically, equitably and responsibly.
  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
  - Influencing Policy
    We advise all levels of government both in the UK and across the world on the the role, impact and importance of genomic and life science research.
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  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
- Campus Connections
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  We are sited on the Wellcome Genome Campus at the very heart of a global hub of fundamental and applied genomic research, education and engagement. It is home to some of the world’s foremost institutes and organisations using genomes and biodata to deliver science with the reach, scale and imagination to solve some of humanity’s greatest challenges and maximise societal benefit.
  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
About
We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
About Us
We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
Read more
Science
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  Our research is organised into six primary Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus. In addition, our Associate Research programmes pioneer new approaches to studying health and disease.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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- Software and Resources
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  We freely and openly provide the global research community with a wide range of genomics software, protocols, and platforms.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  The Sanger Institute has published papers in some of the most prestigious scientific journals. We aim to publish research that will transform biology and improve healthcare.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  Sanger Institute’s Research Policies are designed to provide guidance to help researchers navigate the legislation relating to their research and to ensure that research is ethical and legal.
  Science & technology
  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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  - COVID-19
    The Sanger Institute played a major role in the genomic surveillance of the COVID-19 pandemic, providing large-scale high-throughput sequencing of the SARS-CoV-2 virus and analysis of its evolution and spread in the UK.
  - Sanger Seminar Series
    Throughout the COVID-19 lockdown of 2020-2021 we hosted a series of monthly freely available and open virtual seminars. From using genomic approaches to map all cell types in the human body, understand how cancer develops, and track the evolution and spread of global diseases, our senior scientists and faculty presented the latest developments in their field.
Science
Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease or analytic focus. In all cases, the studies provide insights into human, pathogen, cellular evolution, the phenotypic and hence biological consequences of genome variation and the processes which cause mutations.
Science & technology
Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
Read more
People
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  Our science is founded on the talents, imagination and curiosity of our people. Our wet-lab scientists, bioinformaticians, developers, engineers and skilled administrators work together to deliver cutting-edge research. Join us
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    Our Faculty conceive and deliver our science. Within our strategic framework the Institute’s scientific aspirations are driven by their vision, imagination and intellectual energy.
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    Our Associate Faculty combine their skills and knowledge with the Sanger Institute’s unique abilities to conduct data generation and analysis at scale to pioneer genomic research in new areas.
  - International Fellows
    Our International Fellows Programme empowers early-career researchers with resources, mentorship, and funding to advance genomic research globally.
  - Honorary Faculty
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- All Sanger Staff
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  Almost 1,000 scientists, developers, engineers and skilled professionals work together to deliver the Sanger Institute’s cutting-edge genomic research.
  Join us
  Our science is founded on the talents, imagination and curiosity of our people. Our wet-lab scientists, bioinformaticians, developers, engineers and skilled administrators work together to deliver cutting-edge research. Join us
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People
Almost 1,000 scientists, developers, engineers and skilled professionals work together to deliver the Sanger Institute’s cutting-edge genomic research.
Join us
Our science is founded on the talents, imagination and curiosity of our people. Our wet-lab scientists, bioinformaticians, developers, engineers and skilled administrators work together to deliver cutting-edge research. Join us
Read more
Innovation
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  We deliver therapeutic, diagnostic and production benefits in areas as diverse as cancer, immunology, public health and personalised treatment.
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  We apply our science to benefit society by empowering innovators and engaging with businesses and investors - driven by Sanger Genomics Innovation
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  Read how we benefit society by buiding on the innovative capabilities of our people by engaging with businesses and creating commercial opportunities. We also develop a unique and vibrant ecosystem to establish and grow innovative genomics and biodata businesses.
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  We apply our science to benefit society by empowering innovators and engaging with businesses and investors - driven by Sanger Genomics Innovation
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Innovation
We deliver therapeutic, diagnostic and production benefits in areas as diverse as cancer, immunology, public health and personalised treatment.
Sanger Innovation
We apply our science to benefit society by empowering innovators and engaging with businesses and investors - driven by Sanger Genomics Innovation
Read more
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Latest News

12 Nov 2024

Unlocking the genetics of skin cancer
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8 Nov 2024

A melody of bases: How scaling allows us to set new bars
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4 Nov 2024

Claire Chewapreecha wins the 2024 Nature inspiring women in science: Scientific Achievement prize
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News and Blogs
News and stories Announcements, articles and blogs from the cutting edge of genomic research.
Read more

Flatworm Functional Genomics Initiative (FUGI)

Flatworm Functional Genomics Initiative (FUGI)

Parasites and Microbes

Flatworm Functional Genomics Initiative (FUGI)

A consortium funded by a Wellcome Trust Strategic Award to develop game-changing research tools for the study and manipulation of parasitic flatworm species responsible for the devastating diseases echinococcosis (hydatid disease) and schistosomiasis (bilharzia).

Aims

FUGI proposes three primary aims:

‘Poly-omics’ characterisation of stem cell systems in S. mansoni (neoblast-like somatic cells, S1 vitellocytes and oogonia) and E. multilocularis (germinative cells).
Development of S. mansoni and E. multilocularis reverse genetic toolkits.
Establishment of E. multilocularis and S. mansoni immortal cell lines.

Partners

Dr. Matt Berriman, Wellcome Sanger Institute

Prof. Klaus Brehm, University of Würzburg, Germany

Prof. Paul Brindley, The George Washington University, USA

Dr. James Collins, UT Southwestern Medical Center, USA

Prof. Christoph Grevelding, University of Giessen, Germany

Prof. Christoph Grunau, University Perpignan, France

Prof. Karl Hoffmann, University of Aberystwyth, Wales

Prof. Ludovic Vallier, Cambridge Stem Cell Institute

Consortium Administrator: Jessica Longworth, University of Aberystwyth, Wales

Contact

If you need help or have any queries, please contact us using the details below.

Email: jkl@aber.ac.uk

Sanger people

Photo of Professor Ludovic Vallier

Professor Ludovic Vallier

Honorary Faculty (formerly Senior Group Leader at the Sanger Institute)

Previous Sanger people

Photo of Dr Matt Berriman

Dr Matt Berriman

Former Senior Group Leader

Related groups

Science group

Berriman Group

Parasite Genomics

The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.

Science group

Vallier Group

Pancreatic genetics

The Vallier laboratory studies the basic mechanisms controlling differentiation of human pluripotent cells into pancreas, lung, gut and liver cells.

Wellcome Sanger Institute

Programmes and Facilities

Programme

Parasites and Microbes

We use genomics to study important problems in infectious disease, with a strong desire to develop and refine tools for disease ...

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