Scramble
Scramble is a DNA sequencing file format conversion tool included as part of the Staden io_lib package.
About
Scramble can convert between SAM, BAM and CRAM file formats. It is a part of the Staden io_lib package.
In this regard it shares a similar goal to the Samtools view sub-command, but historically was more performant. (There is no longer any considerable difference between the two.) Now Scramble is still supported, but is also a test bed for more experimental CRAM features, such as the CRAM 4.0 version.
A few related tools in io_lib are scram_flagstat, scram_merge, scram_pileup and cram_index.
Downloads
Scramble is part of the Staden io_lib package and is available from https://github.com/jkbonfield/io_lib.
Further information
To report any problems, please use the github issue tracker.
Io_lib (and hence Scramble) uses a mixture of BSD and MIT OpenSource licenses.
Sanger Institute Contributors
James Bonfield
Principal Software Developer