Active areas of interest include: studying the variation in germline mutation rates across families, mutational processes operative in the germline, the impact of germline genetic mosaicism in offspring, and using somatic mutations to infer the clonal dynamics of germline tissues.
As a member of the INSTALZ consortium, I am also using single cell multi-omics approaches to study somatic heterogeneity in human neuronal cells and their role in Alzheimer’s disease.
My timeline
Became a Faculty Group Leader at the Sanger Institute
Cancer Research UK Career Development Fellowship
Senior PDF in Voets Faculty Single Cell Genomics Group | Sanger Institute
PDF in Hurles Faculty Department of Human Genetics | Sanger Institute
PhD awarded in Medical Genetics | University of Leicester