Dominik Glodzik
Postdoctoral Fellow
Alumni
This person is a member of Sanger Institute Alumni.
Mutatiations in DNA of cancerous and normal cells are uncovered by next-generation sequencing. I apply data science algorithms and statistical programming to extract the knowledge about causes of the mutations.
I am involved in several projects, all of which involve computational analysis of cancer genomes
- In SUPPRESSTEM project, I identify the mutations driving colorectal tumours. We will then use this information to predict which patients are likely to respond to a novel therapy.
- Sequencing whole cancer genomes uncovers the whole new landscape of structural variation. I am studying chromosomal rearrangements, which are another evidence of the mutational processes that operated on the way to breast cancer. Link to BASIS project (http://www.basisproject.eu/).
- In the INSIGNIA project we experimentally try to re-create the patterns of mutations observed in patients’ tumours. I will relate the genomes of the patient tumours to the patterns of experimentally induced mutations.
In my work I enjoy the opportunity to answer one of the fundamental questions about cancer. I am keen to see how data science and machine learning will help us interpret the patients’ tumour. I enjoy public speaking, and explaining our science to the public.